Across TCGA pan-cancer cohorts, LEMD1-DT RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LEMD1-DT’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LEMD1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types LEMD1-DT is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.
THCA, LUAD, and KIRP are the cancer types where LEMD1-DT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LEMD1-DT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.