LEF1-AS1

Across TCGA pan-cancer cohorts, LEF1-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LEF1-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LEF1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LEF1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

KIRP, KIRC, and UCEC are the cancer types where LEF1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.458	0.843	<.001	90	view →
KIRC	OS	Median	II,III,IV	0.454	0.602	.004	85	view →
UCEC	OS	Median	All	0.852	0.580	<.001	72	view →
LGG	DFS	Median	All	0.646	0.812	<.001	54	view →
GBM	OS	Median	All	0.335	0.488	<.001	47	view →
MESO	OS	Quartile	All	0.235	0.534	.001	43	view →
STAD	DFS	Quartile	All	0.310	0.668	.004	41	view →
LUSC	DFS	Tertile	All	0.722	0.549	<.001	24	view →
BLCA	DFS	Median	IV	0.096	0.325	<.001	19	view →
COAD	DFS	Median	All	0.410	0.561	.005	18	view →
THYM	OS	Median	All	0.967	0.734	.003	15	view →
SARC	OS	Tertile	All	0.558	0.793	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LEF1-AS1–KIRP (OS)

Open the KIRP breakdown →