LEF1-AS1

Across TCGA pan-cancer cohorts, LEF1-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LEF1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LEF1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LEF1-AS1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where LEF1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LEF1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.245	<.001	10	view →
HNSC	All	III,IV	+0.173	<.001	10	view →
LUAD	All	II,III,IV	+0.222	<.001	8	view →
KIRP	Male	II,III,IV	−0.250	<.001	7	view →
BLCA	All	III,IV	+0.219	.008	7	view →
LIHC	All	II,III,IV	+0.151	<.001	7	view →
UCEC	All	All	+0.957	<.001	6	view →
BRCA	All	III,IV	+0.324	<.001	6	view →
LUSC	Male	All	+0.309	<.001	6	view →
KICH	All	All	+0.667	<.001	5	view →
STAD	All	II,III,IV	+0.130	<.001	4	view →
READ	All	All	+0.241	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LEF1-AS1–COAD

Open the COAD breakdown →