LECT2

Across TCGA patient cohorts, LECT2 mutation is significantly associated with the RNA expression of many other genes, with 1,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LECT2-associated genes across cancer lineages are HMGB3P3, CENPO, and MIR199B. Each is linked with LECT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LECT2-to-partner and partner-to-LECT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB3P3 grouped by LECT2-low versus LECT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LECT2→partner) and Y-score (partner→LECT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGB3P3 →	+0.070	+3.292	<.001	.001	3	2
UCEC	CENPO →	+0.540	+2.617	.004	.005	3	2
LUAD	MIR199B →	+0.557	+4.888	<.001	.005	3	2
LUAD	TRAJ57 →	+1.518	+4.821	<.001	.003	3	2
LUAD	MIR1251 →	+0.681	+4.888	<.001	.005	3	2
LUAD	VDAC1P12 →	+0.073	+4.984	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,189 associations by consensus.

HMGB3P3 by LECT2 expression — SKCM

Explore this box plot interactively →