LDLRAD4

Across TCGA patient cohorts, LDLRAD4 mutation is significantly associated with the RNA expression of many other genes, with 4,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAD4-associated genes across cancer lineages are RNU6-13P, RNA5SP326, and RNU6-511P. Each is linked with LDLRAD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD4-to-partner and partner-to-LDLRAD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by LDLRAD4-low versus LDLRAD4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD4→partner) and Y-score (partner→LDLRAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-13P →	+0.201	+3.440	.007	.009	3	2
STAD	RNA5SP326 →	+0.257	+3.289	.009	.007	3	2
STAD	RNU6-511P →	+0.569	+3.226	<.001	.003	3	2
STAD	RNA5SP509 →	+0.182	+3.629	<.001	.003	3	2
STAD	RNU6-472P →	+0.167	+3.537	.006	.004	3	2
STAD	RNU6-1146P →	+0.418	+3.294	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

RNU6-13P by LDLRAD4 expression — HNSC

Explore this box plot interactively →