LDLRAD3

Across TCGA patient cohorts, LDLRAD3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,194 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LDLRAD3-associated genes across cancer lineages are SNRPD3, MAPK1, and TOP3B. Each is linked with LDLRAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD3-to-partner and partner-to-LDLRAD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDLRAD3 versus SNRPD3 in BRCA, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD3→partner) and Y-score (partner→LDLRAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNRPD3 →	-0.537	-0.477	.008	.003	3	1
BRCA	MAPK1 →	-1.020	-0.575	.003	.003	3	1
BRCA	TOP3B →	-0.109	-0.464	.005	.005	3	1
BRCA	SLC5A4 →	-0.613	-0.660	<.001	<.001	3	1
BRCA	DDX17 →	-1.064	-0.662	.003	.001	3	1
BRCA	CDKL1 →	-0.503	-0.614	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,194 associations by consensus.

LDLRAD3 vs SNRPD3 — BRCA

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