LDLRAD3

Across TCGA pan-cancer cohorts, LDLRAD3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LDLRAD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LDLRAD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LDLRAD3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where LDLRAD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LDLRAD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.485	<.001	12	view →
KIRP	All	IV	+2.182	<.001	11	view →
COAD	Female	II,III,IV	+1.794	<.001	11	view →
THCA	Male	All	+0.982	<.001	11	view →
LUSC	Female	All	+1.423	<.001	8	view →
HNSC	All	All	+0.510	.001	8	view →
LUAD	All	All	+0.454	.001	7	view →
READ	All	All	+1.473	.002	6	view →
BRCA	All	All	+0.552	<.001	6	view →
KICH	All	All	−0.880	<.001	4	view →
LIHC	Female	All	+0.746	<.001	4	view →
CHOL	Female	All	+2.430	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LDLRAD3–KIRC

Open the KIRC breakdown →