LDLRAD3

Across TCGA patient cohorts, LDLRAD3 mutation is significantly associated with the RNA expression of many other genes, with 1,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAD3-associated genes across cancer lineages are RNA5SP169, OR4S2, and RNU6-662P. Each is linked with LDLRAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD3-to-partner and partner-to-LDLRAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP169 grouped by LDLRAD3-low versus LDLRAD3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD3→partner) and Y-score (partner→LDLRAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP169 →	+0.258	+8.471	<.001	.005	3	2
LUAD	OR4S2 →	+0.018	+5.757	<.001	<.001	3	2
LUAD	RNU6-662P →	+0.302	+3.480	<.001	.005	3	2
LUAD	DEFB115 →	+0.611	+3.894	<.001	.002	3	2
LUAD	RNU6-922P →	+0.259	+3.542	<.001	.004	3	2
STAD	RNA5SP331 →	+0.213	+4.641	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,679 associations by consensus.

RNA5SP169 by LDLRAD3 expression — BRCA

Explore this box plot interactively →