LDLRAD3

Across TCGA patient cohorts, LDLRAD3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAD3-associated genes across cancer lineages are ATM, EGFR_pY1068, and EGFR. Each is linked with LDLRAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD3-to-partner and partner-to-LDLRAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LDLRAD3-low versus LDLRAD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD3→partner) and Y-score (partner→LDLRAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.549	-2.321	.003	.006	3	2
UCEC	EGFR_pY1068 →	-0.343	-3.000	<.001	.001	3	1
UCEC	EGFR →	-0.283	-2.584	<.001	.010	3	1
UCEC	eIF4G →	+0.312	+2.321	.014	.034	3	1
UCEC	FoxM1 →	+0.339	+2.321	.001	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-2.105	.015	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by LDLRAD3 expression — UCEC

Explore this box plot interactively →