LDLRAD3

Across TCGA cell cohorts, LDLRAD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,163 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LDLRAD3-associated GO terms across cancer lineages are Defense response to bacterium, Transcription initiation at RNA polymerase I promoter, and Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with LDLRAD3 in more than 11 cancer types. Because this analysis shows association rather than direction, both LDLRAD3-to-partner and partner-to-LDLRAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to bacterium grouped by LDLRAD3-low versus LDLRAD3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD3→partner) and Y-score (partner→LDLRAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Defense response to bacterium →	-0.136	-1.867	<.001	<.001	2	12
LUNG_NSCLC_LUAD	Transcription initiation at RNA polymerase I promoter →	+0.091	+1.110	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.103	+1.700	.004	.006	3	10
SOFT_TISSUE	DNA-templated transcription initiation →	+0.056	+0.891	<.001	.001	3	10
LUNG_NSCLC_LUAD	Regulation of cardiac muscle contraction →	-0.089	-1.165	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase I →	+0.099	+1.054	.002	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,163 associations by consensus.

Defense response to bacterium by LDLRAD3 expression — LIVER

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