LDLRAD3

Across TCGA cell cohorts, LDLRAD3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDLRAD3-associated genes across cancer lineages are CEACAM3, ST8SIA3, and KRTAP2-4. Each is linked with LDLRAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD3-to-partner and partner-to-LDLRAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM3 grouped by LDLRAD3-low versus LDLRAD3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD3→partner) and Y-score (partner→LDLRAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	ST8SIA3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP2-4 →	+0.049	+4.807	<.001	.006	3	1
LARGE_INTESTINE	PRDM7 →	+0.159	+3.761	.001	.001	3	1
LARGE_INTESTINE	PTH2R →	+0.864	+2.716	<.001	.009	3	1
LARGE_INTESTINE	LRIT1 →	+0.019	+3.257	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CEACAM3 by LDLRAD3 expression — BLOOD_Myeloma

Explore this box plot interactively →