LDLR

Across TCGA patient cohorts, LDLR RNA expression is significantly associated with the RNA expression of many other genes, with 19,538 significant associations in total. ACC shows the largest number of these associations.

The most reproducible LDLR-associated genes across cancer lineages are CSNK1A1, PDLIM5, and SLC35E1. Each is linked with LDLR in more than 32 cancer types. Because this analysis shows association rather than direction, both LDLR-to-partner and partner-to-LDLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDLR versus CSNK1A1 in ACC, with a Pearson correlation of 0.55.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLR→partner) and Y-score (partner→LDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	CSNK1A1 →	+1.774	+3.128	<.001	<.001	3	33
SARC	PDLIM5 →	+1.370	+0.971	<.001	<.001	3	32
ACC	SLC35E1 →	+1.059	+2.244	<.001	<.001	3	32
ACC	CYP51A1 →	+2.198	+3.228	<.001	<.001	3	32
DLBC	MYOF →	+2.142	+1.488	<.001	<.001	3	31
DLBC	ZDHHC5 →	+0.759	+1.192	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,538 associations by consensus.

LDLR vs CSNK1A1 — ACC

Explore this scatter interactively →