LDLR

Across TCGA pan-cancer cohorts, LDLR RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LDLR data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LDLR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LDLR expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

KIRP, BLCA, and MESO are the cancer types where LDLR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.598	0.780	<.001	126	view →
BLCA	OS	Median	All	0.635	0.781	<.001	107	view →
MESO	OS	Median	All	0.261	0.512	<.001	90	view →
UVM	DFS	Tertile	All	0.377	0.833	<.001	78	view →
ACC	DFS	Median	All	0.297	0.811	<.001	61	view →
SKCM	DFS	Tertile	II,III,IV	0.784	0.613	.002	43	view →
KIRC	DFS	Quartile	IV	0.158	0.533	.001	42	view →
LAML	DFS	Tertile	All	0.320	0.594	<.001	30	view →
PAAD	OS	Median	All	0.268	0.518	.001	25	view →
UCS	DFS	Tertile	IV	0.832	0.239	.024	24	view →
COAD	DFS	Quartile	All	0.272	0.736	.005	17	view →
CHOL	OS	Quartile	All	0.249	0.872	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LDLR–KIRP (OS)

Open the KIRP breakdown →