LDLR

Across TCGA patient cohorts, LDLR RNA expression is significantly associated with the protein abundance of many other proteins, with 10,594 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LDLR-associated proteins across cancer lineages are FDFT1, MVD, and NSDHL. Each is linked with LDLR in more than 5 cancer types. Because this analysis shows association rather than direction, both LDLR-to-partner and partner-to-LDLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDLR versus FDFT1 in HNSC, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLR→partner) and Y-score (partner→LDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FDFT1 →	+0.829	+0.754	<.001	<.001	3	6
BRCA	MVD →	+0.428	+0.492	<.001	.003	3	4
HNSC	NSDHL →	+0.455	+0.741	<.001	.001	3	4
HNSC	PIK3C2A_S259 →	+0.571	+0.655	<.001	.002	3	4
OV	ASPSCR1_S275 →	-0.652	-1.348	.007	.002	3	4
GBM	JUNB →	+0.501	+1.106	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,594 associations by consensus.

LDLR vs FDFT1 — HNSC

Explore this scatter interactively →