LDLR

Across TCGA patient cohorts, LDLR protein abundance is significantly associated with the RNA expression of many other genes, with 9,467 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible LDLR-associated genes across cancer lineages are MSMO1, SH2D3A, and TRIP10. Each is linked with LDLR in more than 5 cancer types. Because this analysis shows association rather than direction, both LDLR-to-partner and partner-to-LDLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDLR versus MSMO1 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLR→partner) and Y-score (partner→LDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MSMO1 →	+0.973	+0.664	<.001	<.001	3	6
LSCC	SH2D3A →	+0.538	+0.435	<.001	<.001	3	4
LUAD	TRIP10 →	+0.474	+0.525	<.001	<.001	3	4
GBM	ANXA2 →	+0.884	+0.445	<.001	<.001	3	4
HNSC	AHNAK2 →	+1.082	+0.464	<.001	<.001	3	4
HNSC	ERO1A →	+0.735	+0.496	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,467 associations by consensus.

LDLR vs MSMO1 — GBM

Explore this scatter interactively →