LDLR

Across TCGA patient cohorts, LDLR mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLR-associated genes across cancer lineages are ATM, eEF2, and Caspase-7-cleavedD198. Each is linked with LDLR in more than 2 cancer types. Because this analysis shows association rather than direction, both LDLR-to-partner and partner-to-LDLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LDLR-low versus LDLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLR→partner) and Y-score (partner→LDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.656	-2.584	<.001	.001	3	3
COAD	eEF2 →	+0.356	+2.815	.028	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.046	+2.815	.016	.036	3	2
UCEC	mTOR_pS2448 →	-0.190	-2.584	<.001	.001	3	2
UCEC	Annexin-1 →	+0.493	+2.341	.014	.019	3	2
UCEC	A-Raf_pS299 →	-0.123	-2.222	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by LDLR expression — UCEC

Explore this box plot interactively →