LDLR

Across TCGA cell cohorts, LDLR mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDLR-associated genes across cancer lineages are ELOA3DP, TMEM132D, and ADAM29. Each is linked with LDLR in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLR-to-partner and partner-to-LDLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by LDLR-low versus LDLR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLR→partner) and Y-score (partner→LDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.014	+2.202	.002	.006	3	2
OESOPHAGUS	TMEM132D →	+0.022	+4.392	<.001	.003	3	1
OESOPHAGUS	ADAM29 →	+0.048	+4.017	<.001	.007	3	1
OESOPHAGUS	OR8D2 →	+0.156	+4.017	<.001	.007	3	1
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR5C1 →	+0.022	+4.635	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

ELOA3DP by LDLR expression — LARGE_INTESTINE

Explore this box plot interactively →