LDHD

Across TCGA patient cohorts, LDHD mutation is significantly associated with the RNA expression of many other genes, with 2,221 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHD-associated genes across cancer lineages are RN7SKP112, FRG1HP, and MIR3929. Each is linked with LDHD in more than 2 cancer types. Because this analysis shows association rather than direction, both LDHD-to-partner and partner-to-LDHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP112 grouped by LDHD-low versus LDHD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHD→partner) and Y-score (partner→LDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP112 →	+0.130	+3.070	.006	.004	3	3
UCEC	FRG1HP →	+0.613	+3.828	<.001	<.001	3	2
STAD	MIR3929 →	+0.956	+4.254	<.001	.008	3	2
UCEC	MIA-RAB4B →	+0.058	+1.863	.001	.002	3	2
UCEC	PARD6A →	+0.803	+3.606	<.001	.001	3	2
UCEC	TMEM87A →	+0.573	+3.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,221 associations by consensus.

RN7SKP112 by LDHD expression — SKCM

Explore this box plot interactively →