LDHD

Across TCGA cell cohorts, LDHD mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LDHD-associated genes across cancer lineages are PROP1, PRB4, and PRSS58. Each is linked with LDHD in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHD-to-partner and partner-to-LDHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by LDHD-low versus LDHD-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHD→partner) and Y-score (partner→LDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PROP1 →	+0.015	+3.786	<.001	.004	3	1
PANCREAS	PRB4 →	+0.028	+3.700	.007	.008	3	1
PANCREAS	PRSS58 →	+0.067	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
BLOOD_Lymphoma	OR14K1 →	+0.142	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5AK2 →	+0.063	+6.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PROP1 by LDHD expression — PANCREAS

Explore this box plot interactively →