LDHC

Across TCGA patient cohorts, LDHC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,997 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LDHC-associated GO terms across cancer lineages are Lactate metabolic process, Mitotic spindle assembly, and Regulation of DNA-templated DNA replication. Each is linked with LDHC in more than 20 cancer types. Because this analysis shows association rather than direction, both LDHC-to-partner and partner-to-LDHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lactate metabolic process grouped by LDHC-low versus LDHC-high in ACC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHC→partner) and Y-score (partner→LDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	Lactate metabolic process →	-0.052	-0.629	<.001	.008	1	21
STAD	Mitotic spindle assembly →	+0.055	+0.318	<.001	<.001	3	10
STAD	Regulation of DNA-templated DNA replication →	+0.072	+0.438	<.001	<.001	3	10
STAD	Positive regulation of telomerase RNA localization to Cajal body →	+0.056	+0.298	<.001	<.001	3	10
STAD	Mitochondrial translation →	+0.056	+0.285	<.001	<.001	3	10
STAD	Mitochondrial genome maintenance →	+0.064	+0.476	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,997 associations by consensus.

Lactate metabolic process by LDHC expression — ACC

Explore this box plot interactively →