LDHC

Across TCGA patient cohorts, LDHC protein abundance is significantly associated with the protein abundance of many other proteins, with 5,691 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LDHC-associated proteins across cancer lineages are ADD2, CDK12_S355, and CLASRP_S647. Each is linked with LDHC in more than 3 cancer types. Because this analysis shows association rather than direction, both LDHC-to-partner and partner-to-LDHC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDHC versus ADD2 in GBM, with a Pearson correlation of 0.47.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHC→partner) and Y-score (partner→LDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADD2 →	+0.491	+0.559	<.001	<.001	3	2
BRCA	CDK12_S355 →	-1.903	-0.783	.001	.002	3	2
GBM	CLASRP_S647 →	-0.462	-0.491	<.001	<.001	3	2
GBM	CLASRP_S649 →	-0.460	-0.491	<.001	<.001	3	2
GBM	DOCK4_S1618 →	+1.126	+0.716	<.001	<.001	3	2
CCRCC	ELL →	-0.344	-0.660	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,691 associations by consensus.

LDHC vs ADD2 — GBM

Explore this scatter interactively →