LDHC

Across TCGA patient cohorts, LDHC mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHC-associated genes across cancer lineages are Beclin, EGFR_pY1068, and Heregulin. Each is linked with LDHC in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHC-to-partner and partner-to-LDHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Beclin grouped by LDHC-low versus LDHC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHC→partner) and Y-score (partner→LDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Beclin →	-0.086	-2.999	.043	.035	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.000	.025	.032	3	1
UCEC	Heregulin →	-0.180	-2.459	.001	.019	3	1
UCEC	JNK2 →	+0.240	+2.834	.007	.034	3	1
UCEC	Ku80 →	+0.314	+3.183	.003	.009	3	1
UCEC	p27_pT198 →	+0.126	+3.000	.009	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Beclin by LDHC expression — UCEC

Explore this box plot interactively →