LDHC

Across TCGA cell cohorts, LDHC mutation is significantly associated with the mutation status of many other genes, with 370 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDHC-associated genes across cancer lineages are FZD4, RNF182, and CEP63. Each is linked with LDHC in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHC-to-partner and partner-to-LDHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FZD4 grouped by LDHC-low versus LDHC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHC→partner) and Y-score (partner→LDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FZD4 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	RNF182 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	CEP63 →	+3.422	+4.807	<.001	<.001	1	2
LARGE_INTESTINE	EP400P1 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	ADH7 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	SLC2A7 →	+3.007	+3.584	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

FZD4 by LDHC expression — LARGE_INTESTINE

Explore this box plot interactively →