Across TCGA pan-cancer cohorts, LDHBP3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LDHBP3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LDHBP3 RNA is repressed in tumor relative to normal tissue. In most cancer types LDHBP3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where LDHBP3 tumor–normal differential expression is most reproducible.