Across TCGA pan-cancer cohorts, LDHAL6B mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated LDHAL6B data layer compared with 27 for mass-spec protein and 4 for mutation status.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LDHAL6B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LDHAL6B expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.
CCRCC are the cancer types where LDHAL6B mass-spec protein most reproducibly stratifies survival.