LDB3

Across TCGA patient cohorts, LDB3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,220 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LDB3-associated genes across cancer lineages are CASQ2, PDE2A, and ADH1B. Each is linked with LDB3 in more than 8 cancer types. Because this analysis shows association rather than direction, both LDB3-to-partner and partner-to-LDB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDB3 versus CASQ2 in HNSC, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB3→partner) and Y-score (partner→LDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CASQ2 →	+2.575	+1.145	<.001	<.001	3	9
GBM	PDE2A →	+1.034	+0.613	<.001	<.001	3	9
BRCA	ADH1B →	+1.823	+0.530	<.001	.003	3	9
GBM	ASPA →	+0.813	+0.562	<.001	<.001	3	8
UCEC	RAMP2 →	+0.785	+1.193	.001	<.001	3	8
BRCA	LYVE1 →	+1.621	+0.779	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,220 associations by consensus.

LDB3 vs CASQ2 — HNSC

Explore this scatter interactively →