LDB3

Across TCGA patient cohorts, LDB3 mutation is significantly associated with the RNA expression of many other genes, with 2,999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDB3-associated genes across cancer lineages are TBC1D3P3, BAG3, and CDC7. Each is linked with LDB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LDB3-to-partner and partner-to-LDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3P3 grouped by LDB3-low versus LDB3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB3→partner) and Y-score (partner→LDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TBC1D3P3 →	+0.038	+4.468	<.001	.006	3	3
UCEC	BAG3 →	+0.505	+3.871	<.001	<.001	3	3
UCEC	CDC7 →	+0.620	+2.400	.001	<.001	3	3
HNSC	BAGE2 →	+0.384	+4.074	.009	.002	3	2
HNSC	OR51I2 →	+0.073	+4.725	<.001	<.001	3	2
HNSC	RNU6-127P →	+0.192	+4.763	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,999 associations by consensus.

TBC1D3P3 by LDB3 expression — HNSC

Explore this box plot interactively →