LDB3

Across TCGA cell cohorts, LDB3 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDB3-associated genes across cancer lineages are CCDC182, OR51T1, and HMHB1. Each is linked with LDB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDB3-to-partner and partner-to-LDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC182 grouped by LDB3-low versus LDB3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB3→partner) and Y-score (partner→LDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC182 →	+0.021	+4.369	.001	.008	3	1
SOFT_TISSUE	OR51T1 →	+0.393	+4.417	<.001	.004	3	1
SKIN	HMHB1 →	+0.057	+5.022	<.001	.002	3	1
SKIN	OR6N1 →	+0.191	+4.415	<.001	.007	3	1
CNS	TBATA →	+0.023	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.713	+3.307	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

CCDC182 by LDB3 expression — SOFT_TISSUE

Explore this box plot interactively →