LDB3

Across TCGA cell cohorts, LDB3 mutation is significantly associated with the mutation status of many other genes, with 4,381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDB3-associated genes across cancer lineages are ACOX2, GRIN2B, and XDH. Each is linked with LDB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LDB3-to-partner and partner-to-LDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACOX2 grouped by LDB3-low versus LDB3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB3→partner) and Y-score (partner→LDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ACOX2 →	+5.014	+5.584	.003	.003	1	4
CNS	GRIN2B →	+4.044	+5.000	.008	.008	1	4
BLOOD_Lymphoma	XDH →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	DDX60L →	+4.429	+5.247	.005	.005	1	3
BLOOD_Leukemia	PREX1 →	+2.498	+2.624	.008	.008	1	3
BLOOD_Leukemia	ZNF831 →	+2.820	+3.080	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,381 associations by consensus.

ACOX2 by LDB3 expression — BLOOD_Lymphoma

Explore this box plot interactively →