Across TCGA patient cohorts, LCTL mutation is significantly associated with the RNA expression of many other genes, with 2,643 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCTL-associated genes across cancer lineages are RNA5SP420, GPATCH11, and HOMER1. Each is linked with LCTL in more than 2 cancer types. Because this analysis shows association rather than direction, both LCTL-to-partner and partner-to-LCTL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCTL→partner) and Y-score (partner→LCTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP420 →	+0.462	+1.677	<.001	.004	3	3
UCEC	GPATCH11 →	+0.362	+1.788	.002	.001	3	2
UCEC	HOMER1 →	+0.507	+1.523	.004	.008	3	2
UCEC	RAD17 →	+0.388	+2.828	.001	.001	3	2
UCEC	NDUFAF2 →	+0.537	+4.098	<.001	<.001	3	2
UCEC	NSA2 →	+0.411	+2.058	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,643 associations by consensus.

Exploration

LCTL survival (RNA) · tumor vs normal (RNA) · all LCTL data types