LCT

Across TCGA patient cohorts, LCT RNA expression is significantly associated with the protein abundance of many other proteins, with 11,779 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LCT-associated proteins across cancer lineages are CHEK1, TTK, and SMC2. Each is linked with LCT in more than 3 cancer types. Because this analysis shows association rather than direction, both LCT-to-partner and partner-to-LCT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LCT versus CHEK1 in GBM, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LCT→partner) and Y-score (partner→LCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHEK1 →	+0.736	+0.285	<.001	<.001	3	4
BRCA	TTK →	+0.482	+0.474	<.001	<.001	3	3
GBM	SMC2 →	+0.546	+0.162	<.001	.006	3	3
CCRCC	VPS13C_S737 →	-0.306	-0.143	<.001	<.001	3	3
GBM	WIZ_S1101 →	+0.416	+0.215	<.001	<.001	3	3
BRCA	ZBTB21_S345 →	+0.302	+0.565	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,779 associations by consensus.

LCT vs CHEK1 — GBM

Explore this scatter interactively →