LCT

Across TCGA patient cohorts, LCT mutation is significantly associated with the RNA expression of many other genes, with 6,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCT-associated genes across cancer lineages are APTX, SHROOM4, and GTF3C5. Each is linked with LCT in more than 5 cancer types. Because this analysis shows association rather than direction, both LCT-to-partner and partner-to-LCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APTX grouped by LCT-low versus LCT-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCT→partner) and Y-score (partner→LCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	APTX →	+0.369	+1.950	<.001	<.001	3	6
COAD	SHROOM4 →	-0.855	-2.879	<.001	.001	3	6
STAD	GTF3C5 →	+0.776	+3.601	<.001	.001	3	5
STAD	FAM136A →	+0.550	+3.355	<.001	.004	3	5
COAD	CDCA2 →	+0.648	+3.713	<.001	<.001	3	5
COAD	H2AX →	+0.541	+3.010	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,197 associations by consensus.

APTX by LCT expression — LUAD

Explore this box plot interactively →