LCT

Across TCGA patient cohorts, LCT mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCT-associated genes across cancer lineages are Cyclin-E2, PCNA, and ATM. Each is linked with LCT in more than 4 cancer types. Because this analysis shows association rather than direction, both LCT-to-partner and partner-to-LCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by LCT-low versus LCT-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCT→partner) and Y-score (partner→LCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Cyclin-E2 →	+0.327	+3.010	<.001	.020	3	5
COAD	PCNA →	+0.238	+2.230	.012	.006	3	4
UCEC	ATM →	-0.518	-1.402	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.255	+1.402	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.137	+2.476	<.001	.009	3	3
STAD	c-Kit →	-0.414	-3.321	.003	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

Cyclin-E2 by LCT expression — BRCA

Explore this box plot interactively →