LCT

Across TCGA cell cohorts, LCT RNA expression is significantly associated with the go_rna of many other GO terms, with 1,637 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LCT-associated GO terms across cancer lineages are Heterochromatin formation, Heterochromatin organization, and Epigenetic regulation of gene expression. Each is linked with LCT in more than 8 cancer types. Because this analysis shows association rather than direction, both LCT-to-partner and partner-to-LCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by LCT-low versus LCT-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LCT→partner) and Y-score (partner→LCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.077	+0.066	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Heterochromatin organization →	+0.070	+0.066	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.062	+0.066	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.077	+0.066	<.001	<.001	3	8
BLOOD_Leukemia	Constitutive heterochromatin formation →	+0.047	+0.241	<.001	.003	3	8
LUNG_NSCLC_LUSC	Regulation of centrosome cycle →	+0.081	+0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,637 associations by consensus.

Heterochromatin formation by LCT expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →