Across TCGA patient cohorts, LCN8 mutation is significantly associated with the RNA expression of many other genes, with 376 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN8-associated genes across cancer lineages are WHAMM, MORC1-AS1, and MIR548Y. Each is linked with LCN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN8-to-partner and partner-to-LCN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN8→partner) and Y-score (partner→LCN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WHAMM →	+0.549	+2.523	<.001	.009	3	2
SKCM	MORC1-AS1 →	+0.044	+4.408	<.001	.005	3	2
LUSC	MIR548Y →	+0.502	+5.273	<.001	.006	3	2
UCEC	HYKK →	+0.363	+2.533	.003	.009	3	2
UCEC	ZNF79 →	+0.374	+3.343	.005	.005	3	2
UCEC	HPRT1P2 →	+0.041	+3.113	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

Exploration

LCN8 survival (RNA) · tumor vs normal (RNA) · all LCN8 data types