Across TCGA pan-cancer cohorts, LCN8 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LCN8’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where LCN8 RNA is repressed in tumor relative to normal tissue. In most cancer types LCN8 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.
KICH, KIRP, and BRCA are the cancer types where LCN8 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCN8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.