Across TCGA patient cohorts, LCN8 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN8-associated genes across cancer lineages are IGFBP2, MSH2, and P-Cadherin. Each is linked with LCN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN8-to-partner and partner-to-LCN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN8→partner) and Y-score (partner→LCN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.765	-2.999	.006	.035	3	1
UCEC	MSH2 →	-0.273	-2.973	.006	.035	3	1
UCEC	P-Cadherin →	-0.132	-2.999	.036	.035	3	1
UCEC	Annexin-1 →	+0.601	+3.189	.008	.010	3	1
UCEC	S6_pS240_S244 →	+0.557	+3.459	.001	.005	3	1
UCEC	Smad4 →	-0.130	-3.321	.013	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

LCN8 survival (RNA) · tumor vs normal (RNA) · all LCN8 data types