LCN6

Across TCGA patient cohorts, LCN6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN6-associated genes across cancer lineages are EGFR_pY1068, PCNA, and Annexin-1. Each is linked with LCN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN6-to-partner and partner-to-LCN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LCN6-low versus LCN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN6→partner) and Y-score (partner→LCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.297	-3.169	.018	.019	3	1
UCEC	PCNA →	+0.272	+3.000	.012	.036	3	1
UCEC	Annexin-1 →	+0.726	+3.019	.006	.019	3	1
UCEC	VEGFR2 →	+0.310	+2.335	.038	.020	3	1
UCEC	BRD4 →	+0.353	+2.818	.016	.035	3	1
UCEC	Fibronectin →	-0.408	-3.160	.013	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by LCN6 expression — UCEC

Explore this box plot interactively →