Across TCGA patient cohorts, LCN12 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN12-associated genes across cancer lineages are HMGN1P13, NIPA2P4, and SNORD114-3. Each is linked with LCN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN12-to-partner and partner-to-LCN12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN12→partner) and Y-score (partner→LCN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGN1P13 →	+0.413	+2.376	<.001	.007	3	2
UCEC	NIPA2P4 →	+0.067	+2.930	.002	.002	3	2
COAD	SNORD114-3 →	+0.733	+5.126	.003	.001	3	1
COAD	TRDJ2 →	+1.034	+4.384	.001	.006	3	1
COAD	UQCRBP2 →	+0.265	+5.321	<.001	.001	3	1
COAD	LINC02318 →	+0.042	+4.831	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

Exploration

LCN12 survival (RNA) · tumor vs normal (RNA) · all LCN12 data types