Across TCGA pan-cancer cohorts, LCN12 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LCN12’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LCN12 RNA is repressed in tumor relative to normal tissue. In most cancer types LCN12 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and COAD are the cancer types where LCN12 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCN12 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.