LCN1

Across TCGA patient cohorts, LCN1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN1-associated genes across cancer lineages are Shc_pY317, Bcl-2, and MEK1_p_S217_S221. Each is linked with LCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN1-to-partner and partner-to-LCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by LCN1-low versus LCN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN1→partner) and Y-score (partner→LCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.216	-3.000	.014	.037	3	1
UCEC	Bcl-2 →	-0.437	-2.973	.029	.037	3	1
UCEC	MEK1_p_S217_S221 →	-0.397	-3.000	.011	.037	2	1
UCEC	MSH6 →	-0.651	-3.000	<.001	.037	2	1
UCEC	Src_pY416 →	-0.307	-2.986	.027	.037	2	1
UCEC	Tuberin →	+0.368	+2.817	.018	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Shc_pY317 by LCN1 expression — UCEC

Explore this box plot interactively →