LCN1

Across TCGA pan-cancer cohorts, LCN1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LCN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LCN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCN1 is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.

KIRC, BLCA, and BRCA are the cancer types where LCN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.320	<.001	12	view →
BLCA	All	All	+0.109	.001	8	view →
BRCA	All	III,IV	+0.220	<.001	6	view →
THCA	All	All	+0.108	<.001	6	view →
COAD	Male	All	+0.227	<.001	5	view →
KICH	All	All	+0.091	.004	5	view →
STAD	All	III,IV	+0.107	.032	3	view →
KIRP	All	All	+0.045	.022	3	view →
UCEC	All	All	−0.933	.016	2	view →
PRAD	All	All	−0.653	.006	2	view →
READ	All	III,IV	+0.275	.025	2	view →
HNSC	Male	IV	+0.215	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LCN1–KIRC

Open the KIRC breakdown →