Across TCGA pan-cancer cohorts, LCE5A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LCE5A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LCE5A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCE5A is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUSC, LUAD, and THCA are the cancer types where LCE5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCE5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.108	<.001	6	view →
LUAD	All	II,III,IV	−0.034	.033	2	view →
THCA	Female	All	+0.054	.044	1	view →
LIHC	All	All	+0.014	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LCE5A RNA expression & survival · all LCE5A data types