Across TCGA cell cohorts, LCE3E mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCE3E-associated genes across cancer lineages are SPIC, SPHKAP, and FCGR3B. Each is linked with LCE3E in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE3E-to-partner and partner-to-LCE3E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE3E→partner) and Y-score (partner→LCE3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPIC →	+0.019	+5.415	<.001	.004	3	1
LARGE_INTESTINE	SPHKAP →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FCGR3B →	+0.254	+4.467	<.001	.004	3	1
LARGE_INTESTINE	GKN1 →	+0.047	+4.095	.001	.009	3	1
LARGE_INTESTINE	IQCF6 →	+0.322	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

LCE3E survival (RNA) · tumor vs normal (RNA) · all LCE3E data types