LCE3D

Across TCGA pan-cancer cohorts, LCE3D mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LCE3D’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LCE3D mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LCE3D is over-expressed in tumor.

HNSC and LSCC are the cancer types where LCE3D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCE3D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.066	.007	6	view →
LSCC	Male	II,III,IV	+2.530	.027	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LCE3D–HNSC

Open the HNSC breakdown →