Across TCGA pan-cancer cohorts, LCE2C RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LCE2C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LCE2C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCE2C is over-expressed in tumor, although a few such as LIHC and KIRC show the opposite, repressed pattern.

LUSC, LIHC, and KIRC are the cancer types where LCE2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCE2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.257	.004	4	view →
LIHC	All	All	−0.021	.009	2	view →
KIRC	All	All	−0.010	.028	2	view →
THCA	All	All	+0.064	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LCE2C RNA expression & survival · all LCE2C data types