LCE2B

Across TCGA patient cohorts, LCE2B mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE2B-associated genes across cancer lineages are RNA5SP87, NDUFA5P12, and RNU6-787P. Each is linked with LCE2B in more than 2 cancer types. Because this analysis shows association rather than direction, both LCE2B-to-partner and partner-to-LCE2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP87 grouped by LCE2B-low versus LCE2B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE2B→partner) and Y-score (partner→LCE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP87 →	+0.468	+8.055	<.001	.007	3	3
UCEC	NDUFA5P12 →	+0.172	+2.625	<.001	.005	3	3
COAD	RNU6-787P →	+0.683	+3.870	<.001	.006	3	2
UCEC	RNU6-1289P →	+0.469	+3.437	<.001	.004	3	2
UCEC	MIR532 →	+0.440	+4.830	<.001	<.001	3	2
LUSC	MIR944 →	+0.650	+4.144	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

RNA5SP87 by LCE2B expression — BRCA

Explore this box plot interactively →