Across TCGA patient cohorts, LCE2A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE2A-associated genes across cancer lineages are JNK2, INPP4B, and MEK1. Each is linked with LCE2A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE2A-to-partner and partner-to-LCE2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE2A→partner) and Y-score (partner→LCE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.281	+3.459	.004	.005	3	2
UCEC	INPP4B →	-0.470	-3.321	.003	.009	3	1
UCEC	MEK1 →	+0.537	+3.169	.003	.019	3	1
UCEC	Notch1 →	+0.184	+3.009	.009	.019	3	1
UCEC	Smac →	+0.336	+2.321	.010	.035	3	1
UCEC	Tuberin_pT1462 →	+0.239	+2.321	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

LCE2A survival (RNA) · tumor vs normal (RNA) · all LCE2A data types