Across TCGA patient cohorts, LCE1E mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE1E-associated genes across cancer lineages are MIG-6, TIGAR, and NF2. Each is linked with LCE1E in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE1E-to-partner and partner-to-LCE1E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE1E→partner) and Y-score (partner→LCE1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIG-6 →	+0.223	+3.025	.014	.018	3	1
UCEC	TIGAR →	+0.250	+3.026	.004	.019	3	1
UCEC	NF2 →	+0.260	+3.000	.038	.037	1	1
UCEC	Rab25 →	-0.422	-3.000	.027	.037	1	1
UCEC	Annexin-1 →	+0.976	+3.000	.001	.037	1	1
UCEC	Shc_pY317 →	-0.205	-3.000	.019	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

LCE1E survival (RNA) · tumor vs normal (RNA) · all LCE1E data types