Across TCGA cell cohorts, LCE1E mutation is significantly associated with the mutation status of many other genes, with 308 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCE1E-associated genes across cancer lineages are RPS5, PPP1R3E, and MGME1. Each is linked with LCE1E in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE1E-to-partner and partner-to-LCE1E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE1E→partner) and Y-score (partner→LCE1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPS5 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	PPP1R3E →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	MGME1 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	RASL11B →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	VPS4A →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	RAB40B →	+5.523	+5.523	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 308 associations by consensus.

Exploration

LCE1E survival (RNA) · tumor vs normal (RNA) · all LCE1E data types